To reduce the development of drug-resistant what is zithromax used for bacteria and maintain the effectiveness of zithromax (azithromycin) and other bacterial drugs, zithromax (azithromycin) should be used only to treat or prevent infections that are zithromax 250mg proven or strongly suspected to be caused by bacteria. Description, zithromax (azithromycin tablets and azithromycin for oral suspension) contain the active ingredient azithromycin, an azalide, a subclass of macrolide antibiotics, for oral administration. Azithromycin has the chemical name ( 2R,3S,4R,5R,8R, 10R,11R,12S,13S,14R )- zithromax for diarrhea 13-(2,6-dideoxy-3-, c -methyl-3-, o -methyl-(alpha)-, l-ribo d-xylo Azithromycin is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C 38 H 72 N 2 O 12, and its molecular weight is 749.00. Azithromycin has the following structural formula: Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of C 38 H 72 N 2 O 12 2H 2 O and a molecular weight of 785.0. Zithromax is supplied for oral administration as film-coated, modified capsular shaped zithromax 250mg tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium. Zithromax for oral suspension is supplied in bottles zithromax z pak for sale containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD C Red #40; and. After constitution, each 5 mL of suspension contains 100 what is zithromax used for mg or 200 mg of azithromycin. Pharmacokinetics, following oral administration of a single 500 mg dose (two 250 mg tablets) to 36 fasted healthy male volunteers, the mean (SD) pharmacokinetic parameters were AUC 0-72.3 (1.2) gh/mL; C max.5 (0.2) zithromax and pneumonia g/mL; T max.2 (0.9) hours. With a regimen of 500 mg (two 250 mg capsules * ) on day 1, followed by 250 mg daily (one 250 mg capsule) on days 2 through 5, the pharmacokinetic parameters of azithromycin in plasma in healthy young adults (18-40 years of age) are. C min and C max zithromax 250mg remained essentially unchanged from day 2 through day 5 of therapy. Pharmacokinetic Parameters (Mean total n12, day. Day 5, c max (g/mL).41.24, t max (h).5.2, aUC 0-24 (gh/mL).6.1, c min (g/mL).05.05, urinary Excret. ( dose).5.5 *Azithromycin 250 mg tablets are bioequivalent to 250 mg capsules in the fasted state. Azithromycin 250 mg capsules are no longer commercially available. In a two-way crossover study, 12 adult healthy volunteers (6 males, 6 females) received 1,500 mg of azithromycin administered in single daily doses over either 5 days (two 250 mg tablets on day 1, followed by one 250 mg tablet on days 2-5). Due to limited serum samples on day 2 (3-day regimen) and days 2-4 (5-day regimen the serum concentration-time profile of each subject was fit to a 3-compartment model and the AUC 0-(infinity) for the fitted concentration profile was comparable between the 5-day and 3-day regimens. Pharmackoinetic Parameter mean (SD) 3-Day Regimen 5-Day Regimen. Day 3, day. Day 5 C max (serum, g/mL).44 (0.22).54 (0.25).43 (0.20).24 (0.06) Serum AUC 0-(infinity) (ghr/mL).4 (6.2) *.9 (3.1) * Serum.8.9 hr *Total AUC for the entire 3-day and 5-day regimens Median azithromycin exposure (AUC 0-288 ). Administration of the same total dose with either the 5-day or 3-day regimen may be expected to provide comparable concentrations of azithromycin within MN and PMN leukocytes. Two azithromycin 250 mg tablets are bioequivalent to a single 500 mg tablet. Absorption The absolute bioavailability of azithromycin 250 mg capsules. In a two-way crossover study in which 12 healthy subjects received a single 500 mg dose of azithromycin (two 250 mg tablets) with or without a high fat meal, food was shown to increase C max by 23 but had no effect on AUC. When azithromycin suspension was administered with food to 28 adult healthy male subjects, C max increased by 56 and AUC was unchanged. The AUC of azithromycin was unaffected by co-administration of an antacid containing aluminum and magnesium hydroxide with azithromycin capsules; however, the C max was reduced. Administration of cimetidine (800 mg) two hours prior to azithromycin had no effect on azithromycin absorption. Distribution The serum protein binding of azithromycin is variable in the concentration range approximating human exposure, decreasing from 51.02 g/mL to 7 at 2 g/mL. Following oral administration, azithromycin is widely distributed throughout the body with an apparent steady-state volume of distribution.1 L/kg. Greater azithromycin concentrations in tissues than in plasma or serum were observed. High tissue concentrations should not be interpreted to be quantitatively related zithromax z pak for sale to clinical efficacy. The antimicrobial activity of azithromycin is pH related and appears to be reduced with decreasing. However, the extensive distribution of drug to tissues may be relevant to clinical activity. Selected tissue (or fluid) concentration and tissue (or fluid) to plasma/serum concentration ratios are shown in the following table: azithromycin concentrations following A 500 mg dose (TWO 250 mg capsules) IN adults 1 tissue OR fluid time after dose (h) tissue OR fluid concentration (g/g. Sample was obtained 2-4 hours after the first dose. Sample was obtained 10-12 hours after the first dose.

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